2025.08.05
We are pleased to announce that Keiyo Nakai, Ph.D from SPERA PHARMA (Chemical R&D Laboratory) and Professor Takahiro Jomori from the University of the Ryukyus will present the results of their collaborative research at the 71st Annual Meeting of the Japanese Society of Pharmacognosy, to be held at Sojo University (Kumamoto) on September 14–15, 2025.
★Poster Presentation
Poster Title: Novel amphilectenes and related diterpenoids with anti-HBV activity
from Okinawan marine sponge Stylissa sp.
Authors: 〇Tyas, Trianda Ayuning1, Sharma, Hari A1, Yasuhiro Hayashi2, Keiyo Nakai3,
Kanami Yasumoto4, Mina Hirose5, Junichi Tanaka1, Takahiro Jomori1
（1 University of the Ryukyus, 2 University of Miyazaki, 3 SPERA PHARMA,
4 Tokyo University of Science, 5 Tropical Techno Plus）
Research Summary: The newly discovered amphilectene-type compounds exhibit promising anti-HBV (hepatitis B virus) activity. However, due to their extremely limited availability and light-atom-only skeletons, determining their absolute stereochemistry using conventional single-crystal X-ray diffraction was highly challenging.
To overcome this, we applied SPERA PHARMA’s advanced 3D ED/MicroED technology, which enabled rapid and reliable stereochemical determination from trace amounts of sample.
These compounds have been identified as potential seed compounds for hepatitis B drug discovery. This study highlights how MicroED can significantly accelerate early-stage drug research by providing essential structural insights, even from minute quantities of natural products.
About Our 3D ED / MicroED Services
At SPERA PHARMA, we offer structural analysis solutions using 3D ED/MicroED for a wide range of compounds, including:
• Natural products
• APIs and polymorphs
• Salts and cocrystals
• Metabolites
• Metal complexes
• Formulated products
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