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  • 【Research Achievements】A paper was published in Tetrahedron Letters

【Research Achievements】A paper was published in Tetrahedron Letters


A paper by Masatoshi Yamada and others of the Pharmaceutical Research Division has been published in the academic journal “Organic Process Research & Development” of the American Chemical Society.

【Details of the paper】

Journal: Organic Process Research&Development

Title: Rhodium-Catalyzed Highly Enantioselective Hydrogenation of a Tetrasubstituted Enamine

Publication date: March 1, 2021

Authors: Masatoshi Yamada*, Tomoaki Kato, Tomomi Ikemoto, and Mitsuhisa Yamano



Summary: A paper was published on the asymmetric hydrogenation of tetra-substituted enamines, which was developed as a new synthetic method for developmental compounds during the Takeda era. Hydrogenation of tetra-substituted enamines, which generally undergo stereoselective reactions with difficulty, was successfully achieved with high enantioselectivity and high conversion rate.

A highly efficient catalytic reaction was achieved with a catalytically active species that was presumed to be produced by a combination of an original ruthenium metal catalyst and a weak base, such as potassium carbonate.

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