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[Research Achievement] Breaking Barriers in Crystallography: SPERA PHARMA and Rigaku Achieve Structural Determination of Inseparable Polymorphic Mixtures Using 3D ED / MicroED

A new research paper authored by Keiyo Nakai, Kuniyoshi Miki, Atsushi Kaga, Ryo Anzai, Mitsuhisa Yamano, et al., has been published in Crystal Growth & Design.

 

Journal: 　　Crystal Growth & Design (ASAP)

Title:           　Crystal Structure Determination of Inseparable Polymorphic Mixtures by 3D ED/MicroED

URL: 　　       https://pubs.acs.org/doi/full/10.1021/acs.cgd.5c01477

Authors:       ¹Keiyo Nakai*, ¹Kuniyoshi Miki, ²Takashi Kikuchi, ²Hiroyasu Sato,

                            ²Keigo Takahira, ³Robert Bücker, ²Akito Sasaki, ¹Atsushi Kaga,

                            ¹Ryo Anzai, ¹Mitsuhisa Yamano

Affiliation:     ¹SPERA PHARMA, Inc.　²Rigaku Corporation　³Rigaku Europe SE

 

Summary:

SPERA PHARMA, Inc., in collaboration with Rigaku, has successfully determined the crystal structure of inseparable polymorphic mixtures using cutting-edge 3D Electron Diffraction (3D ED / MicroED) technology.

3D ED / MicroED leverages a transmission electron microscope (TEM) to observe numerous nanocrystals and selectively irradiate targeted crystals with an electron beam. This advanced approach enables structures determination of mixtures that were previously considered impossible using conventional X-ray diffraction methods.

In this study, we tracked an exceptionally challenging case: a mixture of Casopitant mesylate Form 1 and Form 3ーthese polymorphs are inseparable and exhibit nearly identical powder X-ray diffraction (PXRD) patterns. Our team achieved rapid and accurate structure determination, making a significant breakthrough in crystallographic analysis for drug development.

This achievement opens new possibilities for analyzing crystalline powders and complex mixtures that cannot be resolved using traditional X-ray techniques.

 

SPERA PHARMA has received numerous inquiries regarding crystalline powders and mixtures that are difficult to analyze with conventional X-ray methods. We are actively providing solutions through 3D ED/MicroED measurements and committed to supporting your research promptly. Please feel free to contact us for assistance.

 

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