2026.03.02
A co-authored research paper by Keiyo Nakai and Mitsuhisa Yamano (SPERA PHARMA), together with Professor Nozomi Saito and Professor Masanori Tayu of Meiji Pharmaceutical University, has been published in The Journal of Organic Chemistry.
Journal: The Journal of Organic Chemistry
Title: De Novo Synthesis of Multisubstituted Pyrrolidines
Based on a Programmed Radical [2 + 2 + 1] Annulation Strategy
Using Sulfide-Based Electron Donor−Acceptor Catalysis
URL: https://doi.org/10.1021/acs.joc.5c02978
Authors: Kakeru Matsukuma, Masanori Tayu,* Keiyo Nakai, Mitsuhisa Yamano,
Sayaka Ohrui, Tomohisa Yamaguchi, and Nozomi Saito*
In this study, we report a highly selective and novel [2+2+1] radical annulation reaction between a specific N‑hydroxyphthalimide (NHPI) ester and two electronically tuned alkenes, which constitutes the central theme of the work. The structures of the key products obtained were determined using 3D ED/MicroED crystal structure analysis, a technique in which our company has particular expertise.
This achievement has been highly recognized as a significant advancement in the field of synthetic chemistry and was selected for the journal’s Front Cover. Co-author Keiyo Nakai of our Chemical R&D Laboratory commented, “In the structural determination of small-molecule compounds, 3D ED/MicroED is an exceptionally powerful technique that can deliver results with remarkable speed. I believe this method should become increasingly widespread in synthetic chemistry research.”
SPERA PHARMA will continue to leverage the technologies and expertise it has cultivated over the years to provide strong support in addressing our customers’ challenges.
For inquiries regarding MicroED-based structural analysis, please feel free to contact us using the button below.
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