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On-demand webinar now available! MicroED Fundamentals and Applications: Case Studies in Small‑Molecule Drug Structures (2024)

Limitations of X-ray Crystallography and the Value of MicroED

In drug discovery and pharmaceutical development, structural determination can be difficult due to challenges such as poor crystallization or limited sample quantity.
When precise analysis is required—especially for crystal polymorphism—accurate structure determination is essential for research efficiency and informed decision-making.

In response to these challenges, 3D ED / MicroED (Micro Electron Diffraction) has gained global attention as an effective structural analysis method.

MicroED Case Studies at SPERA PHARMA

SPERA PHARMA introduced MicroED in 2024 and has achieved multiple successful results by integrating it with existing analytical technologies.
These achievements have been reported through scientific publications and other disclosures.

To meet growing interest in MicroED fundamentals and applications, we are now offering an archived recording of a webinar held in March 2024.

Part 1 features case studies on small-molecule drugs, including:

・Accurate polymorph identification of selexipag and casopitant mesylate

・Practical measurement approaches for mixtures and natural products

Watch the webinar
https://youtu.be/cKfIJb5uiQw

Learn More About MicroED

MicroED-Related Publications from SPERA PHARMA

2026

De Novo Synthesis of Multisubstituted Pyrrolidines Based on a Programmed Radical [2 + 2 + 1] Annulation Strategy Using Sulfide-Based Electron Donor−Acceptor Catalysis, The Journal of Organic Chemistry
(Joint Research with Meiji Pharmaceutical University)

2025

Structure Determination of Synthesized Nitrosamine Drug Substance-Related Impurities (NDSRIs) Using 3D ED/MicroED, Org. Process Res. Dev. 2025(ASAP),
(Joint Research with Rigaku Corporation)

Crystal Structure Determination of Inseparable Polymorphic Mixtures by 3D ED/MicroED, Crystal Growth & Design (ASAP)
(Joint Research with Rigaku Corporation)

Structural Analysis of Active Pharmaceutical Ingredients in Tablets Using 3D ED/MicroED, Molecular Pharmaceutics, 2025,22,5,2613–2622
(Joint Research with Rigaku Corporation)

2024

Detection of Hydrogen Atoms Using Only 3D ED / MicroED and Contribution to Structure Determining Salts or Cocrystals, Crystal Growth & Design, 2025, 25, 1, 129–135
(Joint Research with Rigaku Corporation)

Photoreaction products of extract from the fruiting bodies of Polyozellus multiplex, Journal of Natural Medicines (Published: 21 March 2024)
(Joint Research with Meiji Pharmaceutical University)

Contact us

If any application matches your challenge, feel free to reach out. We’re happy to discuss how MicroED could support your compound.
https://www.spera-pharma.co.jp/en/inquiry/