Support for drug discovery

New synthetic methodologies found during API process R&D are also able to support drug discovery activities.

For example, we have developed convenient and diversified synthetic methods for pharmacore of drug candidates (e.g. heterocycle), and a reliable functional group transformation method, etc. The synthetic methods can contribute to accelerating drug discovery research timeline, providing large amount of the key intermediates of medicinal chemistry.

Examples of synthesispaper·oral presentation
Synthetic reagent for quinolines (Novel vinamidinium salt)Tetrahedron, 2014, 70, 2370
Synthetic method for cores of kinase inhibitors (α-carboline)Tetrahedron, 2014, 70, 5550
J. Org. Chem, 2015, 80, 1564
Tetrahedron, 2017, 73, 5946
Interphex Japan (2014)
Synthetic method for pyrazolesTetrahedron, 2015, 71, 2833
Interphex Japan (2016)
Synthetic method for naphthalenes (Analogues of lignan type natural products)Tetrahedron, 2006, 62, 8539
Outlook of support research for drug discovery (CMC Publishing, 2008)
Conversion of phenol to aniline (effective Smiles rearrangement)Org. Lett. 2005, 7, 3629
Organic Syntheses, 2007, 84, 325

Inquiries About Service

SPERA provides CMC solutions from early-stage through new drug application.

Contact US

page top