Technology

Modified and sustained release technologies (Dual delayed release granules)

Two kinds of granules coated with different polymers which is melt in specific pH enable dual release of API

By combining two types of Immediate release (IR) and Delayed release (DR) enteric pellets, a longer effective blood plasma concentration for clinical purposes was achieved.

API release from granules is controlled slow in acidic to accelerate in neutral

This technology is applied to treatment of morphine-based long-acting cancer pain (capsule formulation) which is currently marketed in Japan, and has earned a high reputation from clinical sites.