Scale up simulation technology
Using a scale-up simulation technology based on accumulated experiences in chemical engineering, SPERA PHARMA can identify/solve a scale-up challenge in advance, ensuring process robustness and the productivity.
For example, a robust crystallization method for API, with a character of easy oil-downed and a large variation of the distribution of crystal particle size, has been established by our simulation technology. (Cryst. Growth Des., 2014, 14 (11), 6006)
Moreover, a robust and efficient drying process for a hydrate API with high quality in commercial scale has been developed by considering the vacuum drying conditions in detail as a process simulation study. (Separation Process Engineering, 2013, 43, 375)
Item | Examples of simulation technology |
reaction |
- Predict exothermic control by our unique simulation software which incorporates acquisition of exothermic properties using RC1 and property of on-site reaction tank
- Scale-up gas absorption reaction
|
concentration |
- Simulate solvent composition of mixed solvents during simple distillation by our unique software
- Predict concentration time
- Propose optimal concentration method
|
crystallization |
- Scale-up crystallization in consideration of agitation power and time-dependent supersaturation
- Develop operation to obtain desired crystal form and particle size
- Support LCM in terms of API development as cocrystal and optimal salt
|
filtration |
- Evaluate various filtration properties and calculate scale-up by our own software (pressured filtration, centrifugal filtration, depth filtration, filter aid filtration)
- Simulate washing and deliquoring
- Propose optimal filtration technique
|
drying |
- Acquire data in consideration of exhaust velocity by our unique drying equipment and calculate prediction at scale
- Develop drying method to obtain hydrate
- Reduce amount of solvent which is hard to remove
- Prevent aggregation in drying
|
milling |
- Propose optimal milling, scale-up operational condition
|